Invented by Hong Kong

Non-Invasive Analysis of Fetal DNA for Prenatal Screening

Safe

Non-Invasive Analysis of Fetal DNA for Prenatal Screening

To screen for Down syndrome and other chromosomal disorders without risks of miscarriage. Fast! Convenient! Safe!

Know more about Chromosomal disorders

Leading Technologies from the University with Professional Follow-up

University Professors specialized in Pathology will provide support to your Obstetricians.

The Unique Professional Services We Provide

Reliable

We are highly regarded by users for our outstanding performance and high test accuracy for detecting the fetal chromosomal disorders.

Our convenient, fast and reliable services

Invention by the University

The world-leading professional medical team from the University has revolutionized prenatal testing with the “T21” technologies.

Our Technologies

Know more about Chromosomal disorders

Our genetic information is encoded in DNA, which is packaged as chromosomes in our cells. Human cells have 23 pairs of chromosomes (22 pairs of autosomes and one pair of sex chromosomes), giving a total of 46 per cell. Trisomy is one of the most common chromosomal abnormalities.

Chromosomal disorders mostly occur during the formation of a fertilized egg, and are random events. Every parent has a certain likelihood of bearing a baby with chromosomal disorders. Statistics showed that the chance of having a defected baby is positively correlated with the age of pregnancy. There is no proven cure for such defects. Therefore, having a fast and safe prenatal screening helps parents better prepare for their families.

Major chromosomal disorders:

  • Patau Syndrome

    Occurrence 1:5000
    Usually born with a variety of birth defects
  • Edwards Syndrome

    Occurrence 1:3000
    Usually born with a variety of birth defects
  • Down Syndrome

    Occurrence 1:700
    Mental and growth retardation
  • Sex Chromosome Aneuploidies

    Occurrence 1:600 – 1:3000
    Abnormal growth
How are the tests done?

safeT21expressTM adopts the latest DNA sequencing technologies.

The emergence of a new test, safeT21expressTM, opens up an opportunity for mothers to experience a prenatal test which is safe and >99.9% accurate.

  • During pregnancy, the unborn child releases some of its DNA into the blood circulation of its mother.
  • DNA from the unborn child can be obtained by drawing only 10ml of maternal blood.
  • safeT21expressTM analyses the circulating cell-free DNA molecules with next-generation DNA sequencing technologies, and performs bioinformatics analysis.
  • Genetic information from the unborn child can be obtained after analysis.
What is?

safeT21expressTM is a high sensitivity genetics analysis service for the non-invasive prenatal screening of Down syndrome and other disorders. safeT21expressTM is a test that analyses such circulating cell-free DNA molecules with next-generation DNA sequencing technologies, and performs bioinformatics analysis. Genetic information from the unborn child can be obtained, which could include the screening results for:

  • Down syndrome (T21)
  • Edwards syndrome (T18)
  • Patau syndrome (T13)
  • Sex chromosome aneuploidies: 45, X0
    (Turner syndrome)
  • Sex chromosome aneuploidies: 47, XXY
    (Klinefelter syndrome)
  • Sex chromosome aneuploidies: 47, XXX
    (Triple X)
  • Sex chromosome aneuploidies: 47, XYY
    (Jacob syndrome)
  • Microdeletions analysis related to 1p36 deletion syndrome
  • Microdeletions analysis related to 2q33.1 deletion syndrome
  • Microdeletions analysis related to Angelman syndrome
  • Microdeletions analysis related to Cri-du-Chat syndrome
  • Microdeletions analysis related to 22q11 deletion syndrome (include DiGeorge syndrome)
  • Microdeletions analysis related to Langer-Giedion syndrome
  • Microdeletions analysis related to Prader-Willi syndrome

When choosing between prenatal DNA tests, you are suggested to seek advice from your doctor on the following issues:

  • Hong long does it take to get the report? Is it really fast?
  • Is my test supported by University professionals?
  • Is my test a state-of-the-art technology with patent granted?


safeT21expressTM is popular among pregnant women because of the following reasons.

  • Professional follow-up

    University Professors specialized in Pathology will provide support to your Obstetricians to handle positive results or special cases

  • Safe and miscarriage risk free

    The test uses a non-invasive method with no risk of miscarriage

  • Fast

    Reporting result in 3-5 working days after blood collection

  • Accurate

    Accuracy of trisomy detection over 99.9%

  • Simple and Convenient

    Only 10ml of maternal blood is required (fasting is not required)

Our simple test procedures:

The accuracy of the safeT21expressTM test

敏兒安safe21篩檢準確度達99.9%

Prenatal Tests

Although the accuracy of invasive diagnostic tests (e.g. amniocentesis) are high, there are risks of miscarriage. On the other hand, traditional screening tests (e.g. OSCAR) are safe, but are less accurate.

safeT21expressTM opens up an opportunity for mothers to experience a prenatal test which is safe and >99.9% accurate.

About Xcelom

Xcelom was built by a group of biotechnology enthusiasts who strive to make the world a better place. It was founded and is run by the most dedicated inventors, explorers and healthcare professionals who help create your future.

盧煜明教授 Prof. Dennis Lo Research lead in
decoding fetal genomic map
from maternal blood

Hong Kong’s Original Scientific Inventions

In 1997, Xcelom’s founder was the first to report the existence of cell-free fetal DNA in the blood of pregnant women. After years of dedicated research, methods for the non-invasive screening of fetal chromosomal aneuploidies, were successfully achieved. The clinical performances of the test approaches developed by the research team were subsequently validated and confirmed by a number of international research groups and this formed the basis for many of the non-invasive prenatal testing protocols adopted for clinical use worldwide today. Xcelom is the only licensee of the CUHK technologies in Hong Kong to provide the safeT21expressTM test.

News (External web links)

Clinical application

Xcelom is established based on the non-invasive prenatal testing technologies pioneered at CUHK. Xcelom is the exclusive licensee of this CUHK technology in Hong Kong.

With our technology leadership and technical centre at the Hong Kong Science Park, Xcelom now pursues an unparalleled ambition – to serve Hong Kong and the world using world-class technologies with impeccable quality, and become the world’s most essential company that transforms prenatal healthcare. Powered by our visionary biomedical professionals and the inventions, Xcelom is proud to offer our flagship service – safeT21expressTM to every pregnant woman and her babies who deserve the best protection and care.

We run the technology. We dream the technology. We breathe the technology

– because our babies deserve only the best.

And we must deliver it, whatever it takes.

From our Staff Mission, Xcelom